The Flintstones

The Flintstones was the first cartoon (debuted 1960) about cavepeople and there have been at least a couple references to it by Gran:
 * in an earlier episode she talks about stealing other people's ideas, then shouts "yabba dabba doo!" while sliding down a dinosaur tail
 * in Nay Boors she meants "Pebbles and Bam" but is cut off before completing it, when mentioning classic cavepeople names. These were Fred Flintstone's daughter and his friend Barney Rubbles' son.